- Small nucleolar RNA snR60/Z15/Z230/Z193/J17
snoRNA snR60 is a
non-coding RNA (ncRNA) molecule which functions in the modification of othersmall nuclear RNA s (snRNAs). This type of modifiying RNA is usually located in thenucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA snR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .snoRNA snR60 was initially discovered using a computational screen of the "Saccharomyces cerevisiae" genomecite journal |author=Lowe TM, Eddy SR |title=A computational screen for methylation guide snoRNAs in yeast |journal=Science |volume=283 |issue=5405 |pages=1168–71 |year=1999 |pmid=10024243 |doi=] , subsequent experimental screens discoveres plant homoloues Z15, Z230, Z193 and J17cite journal | author = Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH | title = The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa | journal = Nucleic Acids Res. | volume = 31 | issue = 10 | pages = 2601–13 | year = 2003 | pmid = 12736310 | doi = | issn = ] .References
External links
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* [http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/snrs/snr60_ta.php Link to snR60 at the FournierLab's snoRNAdb.]
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