Lysine riboswitch

The Lysine riboswitch is a metabolite binding RNA element found within certain messenger RNAs that serve as a precision sensor for the amino acid lysine. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression. [cite journal | last = Mandal | first = M | coauthors = Boese B, Barrick JE, Winkler WC, Breaker RR | year = 2003 | title = Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria | journal = Cell | volume = 113 | pages = 577–586 | pmid = 12787499 | doi = 10.1016/S0092-8674(03)00391-X] This riboswitches is found in a number of genes involved in lysine metabolism, including lysC. [cite journal | last = Sudarsan | first = N | coauthors = Wickiser JK, Nakamura S, Ebert MS, Breaker RR | year = 2003 | title = An mRNA structure in bacteria that controls gene expression by binding lysine | journal = Genes Dev | volume = 17 | pages = 2688–2697 | pmid = 14597663 | doi = 10.1101/gad.1140003] [cite journal | last = Rodionov | first = DA | coauthors = Vitreschak AG, Mironov AA, Gelfand MS | year = 2003 | title = Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch? | journal = Nucleic Acids Res | volume = 31 | pages = 6748–6757 | pmid = 14627808 | doi = 10.1093/nar/gkg900] The lysine riboswitch has also been identified independently and called the L box. [cite journal | last = Grundy | first = FJ | coauthors = Lehman SC, Henkin TM | year = 2003 | title = The L box regulon: Lysine sensing by leader RNAs of bacterial lysine biosynthesis genes | journal = Proc Natl Acad Sci U S A | volume = 100 | pages = 12057–12062 | pmid = 14523230 | doi = 10.1073/pnas.2133705100]

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