L-myc internal ribosome entry site (IRES)
- L-myc internal ribosome entry site (IRES)
The L-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of L-myc that allows cap-independent translation. L-myc undergoes translation via the internal ribosome entry site and bypasses the typical eukaryotic cap-dependent translation pathway [1] . The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis.
References
* [1] cite journal | last = Jopling | first = CL | coauthors = Spriggs KA, Mitchell SA, Stoneley M, Willis AE | year = 2004 | title = L-Myc protein synthesis is initiated by internal ribosome entry | journal = RNA | volume = 10 | pages = 287–298 | pmid = 14730027 | doi = 10.1261/rna.5138804
External links
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