Hepatitis C virus (HCV) cis-acting replication element (CRE)

The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication. [cite journal | last = You | first = S | coauthors = Stump DD, Branch AD, Rice CM | year = 2004 | title = A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication | journal = J Virol | volume = 78 | pages = 1352–1366 | pmid = 14722290 | doi = 10.1128/JVI.78.3.1352-1366.2004]

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