Gammaretrovirus core encapsidation signal

The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly. [cite journal | last = D'Souza | first = V | coauthors = Dey A, Habib D, Summers MF | year = 2004 | title = NMR structure of the 101-nucleotide core encapsidation signal of the Moloney Murine Leukemia Virus | journal = J Mol Biol | volume = 337 | pages = 427–442 | pmid = 15003457 | doi = 10.1016/j.jmb.2004.01.037] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation. [cite journal | last = D'Souza | first = V | coauthors = Summers MF | year = 2004 | title = Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus | journal = Nature. | volume = 431 | pages = 586–590 | pmid = 15457265 | doi = 10.1038/nature02944] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix.

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