FMN riboswitch (RFN element)

FMN riboswitch (RFN element)

The FMN riboswitch (also known as RFN element) is a highly conserved RNA element that is found frequently in the 5'-untranslated regions of prokaryotic mRNAs that encode for flavin mononucleotide (FMN) biosynthesis and transport proteins. This element is a metabolite-dependent riboswitch that directly binds FMN in the absence of proteins. In "Bacillus subtilis", the riboswitch most likely controls gene expression by causing premature transcription termination within the 5' untranslated region of the ribDEAHT operon and precluding access to the ribosome-binding site of ypaA mRNA.cite journal | last = Winkler | first = WC | coauthors = Cohen-Chalamish S, Breaker RR | year = 2002 | title = An mRNA structure that controls gene expression by binding FMN | journal = Proc Natl Acad Sci U S A | volume = 99 | pages = 15908–15913 | pmid = 12456892 | doi = 10.1073/pnas.212628899]

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  • Riboswitch — In molecular biology, a riboswitch is a part of an mRNA molecule that can directly bind a small target molecule, and whose binding of the target affects the gene s activity.cite journal | author = Tucker BJ, Breaker RR | title = Riboswitches as… …   Wikipedia

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