CtRNA

CtRNA

Rolling circle replication plasmids contain a number of mechanisms to maintain a low copy number. One of these methods is to transcribe a small RNA called ctRNA (for counter-transcribed RNA) than is transcribed on the opposite strand to RepB the replication initiation protein. ctRNA binds to the mRNA of repB and causes translational inhibition [cite journal | last = Venkova-Canova | first = T | coauthors = Patek M, Nesvera J | year = 2003 | title = Control of rep gene expression in plasmid pGA1 from Corynebacterium glutamicum | journal = J Bacteriol | volume = 185 | pages = 2402–2409 | pmid = 12670963 | doi = 10.1128/JB.185.8.2402-2409.2003] .

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