Aphthovirus internal ribosome entry site (IRES)

Aphthovirus internal ribosome entry site (IRES)

This family represents the internal ribosome entry site (IRES) of the the "aphthoviruses". [cite journal | last = Fernandez-Miragall | first = O | coauthors = Martinez-Salas E | year = 2003 | title = Structural organization of a viral IRES depends on the integrity of the GNRA motif | journal = RNA | volume = 9 | pages = 1333–1344 | pmid = 14561883 | doi = 10.1261/rna.5950603] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F. [cite journal | last = Kolupaeva | first = VG | coauthors = Pestova TV, Hellen CU | year = 2000 | title = Ribosomal binding to the internal ribosomal entry site of classical swine fever virus | journal = RNA | volume = 6 | pages = 1791–1807 | pmid = 11142379 | doi = 10.1017/S1355838200000662]

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