APC internal ribosome entry site (IRES)

APC internal ribosome entry site (IRES)

The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC).It is thought that IRES-mediated translation of APC is important for an apoptotic cascade [1] .

References

* [1] cite journal | last = Heppner | first = Goss K | coauthors = Trzepacz C, Tuohy TM, Groden J | year = 2002 | title = Attenuated APC alleles produce functional protein from internal translation initiation | journal = Proc Natl Acad Sci U S A | volume = 99 | pages = 8161–8166 | pmid = 12034871 | doi = 10.1073/pnas.112072199

External links

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