Alpha operon ribosome binding site

Alpha operon ribosome binding site

The alpha operon ribosome binding site in bacteria is surrounded by this complex pseudoknotted RNA structure. Translation of the mRNA produces 4 ribosomal protein products, one of which (S4) acts as a translational repressor by binding to the nested pseudoknot region. The mechanism of repression is thought to involve a conformational switch in the pseudoknot region and ribosome entrapment. [cite journal | last = Schlax | first = PJ | coauthors = Xavier KA, Gluick TC, Draper DE | year = 2001 | title = Translational repression of the "Escherichia coli" alpha operon mRNA: importance of an mRNA conformational switch and a ternary entrapment complex | journal = J Biol Chem | volume = 276 | pages = 38494–38501 | pmid = 11504736 | doi = 10.1074/jbc.M106934200]

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