Ganoderic acid

Chembox new
Name=Ganoderic acid A
ImageFile=Ganoderic acid.pngImageSize=200px
IUPACName= (2"R",6"R")-6- [(5"R",7"S",10"S",13"R",14"R",15"S",17"R")
-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,
11-dioxo-2,5,6,7,12,15,16,17
-octahydro-1H-cyclopenta [a] phenanthren-17-yl]
-2-methyl-4-oxoheptanoic acid
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Section1= Chembox Identifiers
CASNo=81907-62-2
PubChem=471002
SMILES=CC(CC(=O)CC(C)C(=O)O)C1CC(C2(C1(CC(=O)C3=C2C(CC4C3(CCC(=O)C4(C)C)C)O)C)C)O
Section2= Chembox Properties
Formula=C₃₀H₄₄O₇
MolarMass=516.67
Appearance=
Density=
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Section3= Chembox Hazards
MainHazards=
FlashPt=
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Ganoderic acids are a class of closely related triterpenes found in "Ganoderma" mushrooms. For thousands of years, the fruiting bodies of "Ganoderma" fungi have been used in traditional medicines in East Asia. [T. Mizuno, G. Wang, J. Zhang, H. Kawagishi, T. Nishitoba and J. Li, "Food Rev. Intern." 11 (1995), p. 151] Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection,Fact|date=January 2008 anti-tumor effects, [Wang, Guan; Zhao, Jian; Liu, Jianwen; Huang, Yongping; Zhong, Jian-Jiang; Tang, Wen. Enhancement of IL-2 and IFN-g expression and NK cells activity involved in the antitumor effect of ganoderic acid Me in vivo. "International Immunopharmacology " (2007), 7(6), 864-870] and 5-alpha reductase inhibition. [Liu, Jie; Kurashiki, Kenji; Shimizu, Kuniyoshi; Kondo, Ryuichiro. Structure-activity relationship for inhibition of 5a-reductase by triterpenoids isolated from Ganoderma lucidum. " Bioorganic & Medicinal Chemistry " (2006), 14(24), 8654-8660. ]

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