Plakohypaphorine

Plakohypaphorines are iodine-containing indole alkaloids named for their similarity to hypaphorine, another alkaloid related to the amino acid tryptophan. First reported in the Caribbean sponge "Plakortis simplex" in 2003, plakohypaphorines A-C were the first iodine-containing compounds based on the indole ring structure to be discovered in nature. Plakohypaphorines D-F, also found in "P. simplex", were reported in 2004 by a group including the researchers who discovered the original plakohypaphorines.

References

*Borrelli, Francesca, et al., 2003. "Plakohypaphorines A-C, Iodine-Containing Alkaloids from the Caribbean Sponge" Plakortis simplex. European Journal of Organic Chemistry. 2003(2), pp. 284-287.
*Borrelli, Francesca, et al., 2004. "Iodinated Indole Alkaloids From Plakortis simplex, New Plakohypaphorines and an Evaluation of Their Antihistamine Activity". European Journal of Organic Chemistry. 2004(15), pp. 3227-3232.