Embryoid body

Embryoid body

Embryoid bodies are aggregates of cells derived from embryonic stem cells, and have been studied for years with mouse embryonic stem cells. Cell aggregation is imposed by hanging drop, plating upon non-tissue culture treated plates or spinner flasks; either method prevents cells from adhering to a surface to form the typical colony growth. Upon aggregation, differentiation is initiated and the cells begin to a limited extent to recapitulate embryonic development. Though they cannot form trophectodermal tissue (which includes the placenta), cells of virtually every other type present in the organism can develop.

The aggregate, while first simply appearing as a ball of cells, takes on an increasingly more complex appearance, becoming after a few days a hollow ball (cystic embryoid body), and next forms internal structures such as a yolk sac, and cardiomyocytes, heart muscle cells which beat in a rhythmic pattern to circulate nutrients within the increasingly larger embryoid body.


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  • Induced pluripotent stem cell — Induced pluripotent stem cells, commonly abbreviated as iPS cells or iPSCs, are a type of pluripotent stem cell artificially derived from a non pluripotent cell, typically an adult somatic cell, by inducing a forced expression of certain genes.… …   Wikipedia

  • EB — elective abortion; electron beam; elementary body; embryoid body; emotional behavior; endometrial biopsy; epidermolysis bullosa; Epstein Barr [virus]; esophageal body; estradiol benzoate; Evans blue * * * elementary body …   Medical dictionary

  • EB — • elective abortion; • electron beam; • elementary body; • embryoid body; • emotional behavior; • endometrial biopsy; • epidermolysis bullosa; • Epstein Barr [virus]; • esophageal body; • estradiol benzoate; • Evans blue …   Dictionary of medical acronyms & abbreviations

  • Embryonic stem cell — Embryonic stem cells (ES cells) are stem cells derived from the inner cell mass of an early stage embryo known as a blastocyst. Human embryos reach the blastocyst stage 4 5 days post fertilization, at which time they consist of 50 150 cells.… …   Wikipedia

  • stem cell — Cell Biol. a cell that upon division replaces its own numbers and also gives rise to cells that differentiate further into one or more specialized types, as various B cells and T cells. [1880 85] * * * ▪ biology Introduction  an undifferentiated… …   Universalium

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