4-Hydroxy-3-nitrobenzenearsonic acid

Chembox new
ImageFile = Roxarsone.png ImageSize = 150px
IUPACName = 4-Hydroxy-3-nitrobenzenearsonic acid
OtherNames = Roxarson Roxarsone 2-Nitrophenol-4-arsonic acid
Section1 = Chembox Identifiers
CASNo = 121-19-7
PubChem =
SMILES =
Section2 = Chembox Properties
Formula = C₆H₆AsNO₆
MolarMass = 263.04
Appearance =
Density =
MeltingPt = >300 °C
BoilingPt =
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Section3 = Chembox Hazards
MainHazards = Toxic
FlashPt =
Autoignition =

4-Hydroxy-3-nitrobenzenearsonic acid is an organic compound that is widely used as a food additive for chickens. The molecule is a derivative of phenylarsonic acid C₆H₅As(O)(OH)₂. This organoarsenic compound, usually under the tradename Roxarsone, has attracted attention because of the possibility that it contaminates the environment and the food chain with arsenic. 1M kilograms of this chemical was produced in 2006 in the US. [Hileman, B. “Arsenic in Chicken Production” Chemical and Engineering News April 9, 2007, pp34-35.] This compound was first reported in a 1923 British patent which describes the nitration and diazatization of arsanilic acid. [GB 226255 19230718]

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*cite journal
author = J. R. Garbarino, A. J. Bednar, D. W. Rutherford, R. S. Beyer, and R. L. Wershaw
title = Environmental Fate of Roxarsone in Poultry Litter. I. Degradation of Roxarsone during Composting
journal = Environ. Sci. Technol.
year = 2003
volume = 37
issue = 8
pages = 1509–1514
doi = 10.1021/es026219q S0013-936X(02)06219-3
*cite journal
author = Chiou P. W.-S.; Chen K.-L.; Yu B.;
title = Effects of roxarsone on performance, toxicity, tissue accumulation and residue of eggs and excreta in laying
journal = Journal of the science of food and agriculture
year = 1997
volume = 74
issue = 2
pages = 229–236
doi = 10.1002/(SICI)1097-0010(199706)74:2<229::AID-JSFA793>3.0.CO;2-F
doilabel = 10.1002/(SICI)1097-0010(199706)74:2229::AID-JSFA7933.0.CO;2-F
*cite journal
author = R. L. Wershaw, J. R. Garbarino, and M. R. Burkhardt
title = Roxarsone in Natural Water Systems
journal =
year =
volume =
pages =
url = http://water.usgs.gov/owq/AFO/proceedings/afo/pdf/Wershaw.pdf
*cite journal
author = KB Kerr, JR Narveson, FA Lux
title = Toxicity of an organic arsenical, 3-nitro-4-hydroxyphenylarsonic acid. Residues in chicken tissues
journal = Journal of Agricultural and Food Chemistry
year = 1969
volume =
pages = 1400
doi =