Junctional epidermolysis bullosa
- Junctional epidermolysis bullosa
Junctional epidermolysis bullosa (JEB), or Epitheliogenesis Imperfecta (EI), is a genetic disorder found in horses. Although affected foals may be born healthy, they die at birth.
Breeds affected
JEB has documented in Belgian drafts, American Cream Draft, Breton drafts, Comtois, and American Saddlebreds. Of these horses, 12% of Belgians and 4% of Saddlebreds are thought to carry the disorder.
ymptoms, Causes, and Prognosis
JEB causes defect in the action of the protein needed to connect the dermis to the epidermis. This produces many symptoms, including:
* hair and skin loss, especially over pressure points (hock, elbows and stifle, fetlocks, and hip). These patches of skin loss grow over time.
* sloughing of the hoof, and ulcers around the coronary band
* oral ulcers, especially around the teeth
* incisors in at birth
There is no known treatment. Foals are usually euthanized after diagnosis, due to the pain associated with the disease. Those that are not euthanized usually die of infection within 2 weeks.
ources
"Testing for Genetic Diseases." "Equus 353". pp 42-43.
Wikimedia Foundation.
2010.
Look at other dictionaries:
junctional epidermolysis bullosa — n any of several forms of epidermolysis bullosa that are marked esp. by usu. severe blister formation between the epidermis and basement membrane often accompanied by involvement of the mucous membranes (as of the mouth or esophagus) and that are … Medical dictionary
Mitis junctional epidermolysis bullosa — Classification and external resources OMIM 226650 Mitis junctional epidermolysis bullosa (also known as Nonlethal junctional epidermolysis bullosa ) is a skin condition characterized by scalp and nail lesions, also associated with periorificial… … Wikipedia
Cicatricial junctional epidermolysis bullosa — is a skin condition characterized by blisters that heal with scarring.[1]:557 It was characterized in 1985.[2] It is not included in OMIM. See also Epidermolysis bullosa Skin lesion References … Wikipedia
epidermolysis bullosa — epidermolysis bul·lo·sa bə lō sə n any of a group of inherited disorders of variable severity marked esp. by the formation of large fluid filled blisters which develop chiefly in response to minor mechanical trauma see dystrophic epidermolysis… … Medical dictionary
epidermolysis bullosa junctionalis — junctional e. bullosa … Medical dictionary
Epidermolysis bullosa — (EB) is a rare genetic disease characterized by the presence of extremely fragile skin and recurrent blister formation, resulting from minor mechanical friction or trauma. The condition was brought to public attention in the UK through the… … Wikipedia
epidermolysis bullosa letalis — the Herlitz type of junctional e. bullosa … Medical dictionary
epidermolysis — A condition in which the epidermis is loosely attached to the corium, readily exfoliating or forming blisters. [epidermis + G. lysis, loosening] e. bullosa [MIM*131800] a group of inherited chronic noninflammatory skin diseases in which large… … Medical dictionary
JEB — junctional epidermolysis bullosa … Medical dictionary
JEB — • junctional epidermolysis bullosa … Dictionary of medical acronyms & abbreviations
