- Acylfulvene
Chembox new
ImageFile=acylfulvene.png
ImageSize=200px
IUPACName=(5'R)-5'-hydroxy-2',5',7'-trimethyl-4'-spiro [cyclopropane-1,6'-indene] one
OtherNames=
Section1= Chembox Identifiers
CASNo=
PubChem=365701
SMILES=CC1=CC2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C
Section2= Chembox Properties
Formula=C14H16O2
MolarMass=216.27564
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=Acylfulvene is a
cytotoxin that is related toilludin . Illudin itself can be extracted from the jack o'lantern mushroom "(Omphalotus olearius )". Acylfulvene is a compound that can be utilized towards the treatment of a wide assortment of cancers and tumors. It is thought that the acylfulvene compound cripples tumors byDNA alkylation (seeDNA methylation ), but the exact mechanism of their actions are not determined.At present,
paclitaxel (Taxol) is the drug of choice to contain tumors and cancers, but researchers claim that the efficacy of acylfulvene to fight various tumors is many times that of paclitaxel. The production and thus the use of acylfulvene is hampered by the fact that the extraction of illudin from mushrooms is difficult and also, at the present moment, acylfulvene is difficult to synthesize. Research on the biochemical interactions of acylfulvene is being conducted at the University of Missouri. [ [http://pubs.acs.org/cen/news/84/i38/8438acylfulvenes.html Chemical & Engineering News: Latest News - Acylfulvene Attack ] ]References
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