- Solenoid (DNA)
The solenoid defines the packing of
DNA as a 30nm fiber ofchromatin and results from the helical winding of at least fivenucleosome strands.In
eukaryotic cells, 146 bp ofDNA are wrapped approximately 1.65 times around ahistone octamer (each histone consists of 2 H2A, H2B dimers, and H3, H4 tetramer) which together are called a nucleosome.Histone H1 , which is not part of the binding histones, tightens the DNA bound to the eight protein complex. The nucleosomes, which at this point resemblebead s on a string, are further compacted into a helical shape via the NH2 terminal protein interactions of the octameric histones, called a solenoid.DNA packed into solenoids, unlike DNA in nucleosome form, is not transcriptionally active. With more packing, solenoids are able to become increasingly more packed, forming chromosomes. At this point, solenoids coil around each other to form a loop (anywhere from 20 to 80,000 base pairs), followed by a rosette (consisting of six connected loops), then a coil, and at last, two
chromatids . The end result is themetaphase chromosome . The completely condensedchromatin has a diameter of up to 600 nm.See also
Chromatin References
cite book
last = Latchman
first = David
authorlink =
coauthors =
title = Eukaryotic Transcription Factors: Fourth Edition
publisher = Elsevier
date = 2004
location = London
pages = 2-3
url =
doi =
id =
isbn =
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