MSCRAMM

MSCRAMM

MSCRAMM (Microbial surface components recognizing adhesive matrix molecules). The MSCRAMM proteins are critical for the initial attachment of bacteria to host, providing a critical step to establish infection.

Examples include protein a, clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from "Staphylococcus aureus" and SdrG from "Staphylococcus epidermidis". All of these MSCRAMMs bind to fibrinogen except protein a that binds IgG, but also other targets for MSCRAMMs are known, such as fibronectin.

The MSCRAMMs have mainly been studied in Gram positive pathogens and are promising drug targets.

The monoclonal antibody Aurexis (Inhibitex, Inc.) is targeted against ClfA and has been tested in a phase II trial.

S.aureus MSCRAMMs:Clumping factor A (ClfA)Fibronectin binding protein a (FnbpA)Fibronectin binding protein b (fnbpB)Protein A

S.epidermidis MSCRAMMs:SdrG

Streptococcus:Protein G


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