Intimin

Intimin

Intimin is a virulence factor (adhesin) of EPEC ("e.g." "E. coli" ) and EHEC ("e.g. E. coli" ) "E. coli" strains. It is an attaching and effacing (A/E) protein which with other virulence factors is responsible for enteropathogenic and enterohaemorrhagic diarrhoea.

Intimin is expressed on the bacterial cell surface where it can bind to its receptor Tir (Translocated intimin receptor). Tir, along with over 25 other bacterial proteins, is secreted from attaching and effacing "E. coli" directly into the cytoplasm of intestinal epithelial cells by a Type three secretion system. Once within the cytoplasm of the host cell, Tir is inserted into the plasma membrane, allowing surface exposure and intimin binding.

External links

* [http://ca.expasy.org/cgi-bin/get-sprot-entry?P43261] UniProt/Swiss-Prot page on Intimin


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