- Langerin
Langerin is a type II transmembrane cell surface receptor produced by
Langerhans cell s. [cite journal |author=Valladeau, J. |coauthors=V. Clair-Moninot, C. Dezutter-Dambuyant, J.-J. Pin, A. Kissenpfennig, M.-G. Mattéi, S. Ait-Yahia, E.E.M. Bates, B. Malissen, F. Koch, F. Fossiez, N. Romani, S. Lebecque and S. Saeland |title=Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues |journal=The Journal of Immunology |volume=168 |issue= |pages=782-792 |year=2002 |pmid=11777972 |doi=] [cite journal |author=Valladeau, J. |coauthors=O. Ravel, C. Dezutter-Dambuyant, K. Moore, M. Kleijmeer, Y. Liu, V. Duvert-Frances, C. Vincent, D. Schmitt, J. Davoust, C. Caux, S. Lebecque and S. Saeland |title=Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules |journal=Immunity |volume=12 |issue=1 |pages=71-81 |year=2000 |pmid=10661407 |doi=]Langerin on mucosal Langerhans cells of the human genital
epithelium binds toHIV-1 and subsequently internalizes it intoBirbeck granules to be degraded. [cite journal |author=de Witte, L. |coauthors=A. Nabatov, M. Pion, D. Fluitsma, M. de Jong, T. de Gruijl, V. Piguet, Y. van Kooyk and T. Geijtenbeek |title=Langerin is a natural barrier to HIV-1 transmission by Langerhans cells |journal=Nature Medicine |volume=13 |issue=3 |pages=367–71 |year=2007 |pmid=17334373 |doi=] [cite journal |author=Turville, S. |coauthors=J. Wilkinson, P. Cameron, J. Dable and A.L. Cunningham |title=The role of dendritic cell C-type lectin receptors in HIV pathogenesis |journal=Journal of Leukocyte Biology |volume=74 |issue= |pages=710-718 |year=2003 |pmid=12960229 |doi=]See also
*
Paul Langerhans
*Langerhans cell References
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