Prokaryotic release factors
- Prokaryotic release factors
There are three known prokaryotic release factors involved in the termination of translation.
* "RF1" recognize stop codons UAG and UAA.
* "RF2" recognize stop codons UGA and UAA.
* "RF3" promotes termination by either factor by accelerating dissociation.
The release factors provide the means of termination by having a conformation that mimics that of tRNA molecules. The decoding release factor binds to the A site of the ribosome and directly recognise the stop codon [cite web|url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7806547&dopt=Abstract |accessdate=2006-11-28|title=Direct recognition of mRNA stop signals by Escherichia coli polypeptide chain release factor two.] . Once RF1 (or RF2) and RF3 are bound to the ribosome, the polypeptide is released, and the ribosome and release factors dissasemble, thus completing the process of translation ][cite web|url=http://www.jbc.org/cgi/content/abstract/278/17/15095|accessdate=2006-11-28|title=Mapping Functionally Important Motifs SPF and GGQ of the Decoding Release Factor RF2 to the Escherichia coli Ribosome by Hydroxyl Radical Footprinting.] .]References
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