Shq1

Shq1p is a protein involved in the rRNA processing pathway. It was discovered by Pok Yang in the [http://www.chem.ucla.edu/dept/Faculty/chanfreau/index.html Chanfreau laboratory] at UCLA. Depletion of Shq1p has led to decreased level of various H/ACA box snoRNAs (H/ACA box snoRNAs are responsible for pseuduridylation of pre-rRNA) and certain pre-rRNA intermediates.Yang PK, Rotondo G, Porras T, Legrain P, Chanfreau G. The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis. J Biol Chem. 2002 Nov 22;277(47):45235-42.]

Background

During the synthesis of eukaryotic ribosomes, four mature ribosomal RNAs (the 5S, 5.8S, 18S, and 25S) must be synthesized. Three of these rRNAs (5.8S, 18S, and 25S) come from a single pre-rRNA known as the 35S. Although many of the intermediates in this rRNA processing pathway have been identified in the last thirty years, there are still a number of proteins involved in this process whose specific function is unknown.

Function

Shq1, a protein thought to play a role in the stablization and/or production of box H/ACA snoRNA, is still uncharacterized. It has been proposed that Shq1, along with Naf1p, is involved in the initial steps of the biogenesis of H/ACA box snoRNPs (box H/ACA snoRNAs form complexes with proteins, thereby forming snoRNPs) because of its association with certain snoRNP proteins during the snoRNP’s maturation, while showing very little association with the mature snoRNP complex.Yang PK, Rotondo G, Porras T, Legrain P, Chanfreau G. The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis. J Biol Chem. 2002 Nov 22;277(47):45235-42.] Despite the known involvement of Shq1 in H/ACA box snoRNP's production, the exact function of this protein in the overall rRNA processing pathway is still unknown.

ee also

*rRNA
*snoRNA
*Ribosomes
*Eukaryotic translation
*Proteins

References

External links

* [http://www.chem.ucla.edu/dept/Faculty/chanfreau/index.html Chanfreau laboratory]
* [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=shq1 Shq1 gene in yeast genome]