- Cortexolone
Chembox new
ImageFile=cortexolone.png
ImageSize=200px
IUPACName= (8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta [a] phenanthren-3-one
OtherNames=
Section1= Chembox Identifiers
CASNo=152-58-9
PubChem=440707
SMILES=CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C
Section2= Chembox Properties
Formula=C21H30O4
MolarMass=346.4605
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Density=
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Section3= Chembox Hazards
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Autoignition=Cortexolone or cortodoxone or 11-
deoxycortisol or 11-desoxycortisol or 11-deoxyhydrocortisone or 11-desoxyhydrocortisone or Reichstein's Substance S or, most commonly, Compound S, is asteroid that can be oxygenated tocortisol (hydrocortisone). It was first synthesized byTadeusz Reichstein .On April 5, 1952,
biochemist Durey Peterson andmicrobiologist Herbert Murray atUpjohn published the first report of a breakthrough fermentation process for the microbial 11α-oxygenation of steroids (e.g.progesterone ) in a single step by commonmold s of the orderMucorales . [cite journal |author=Peterson DH, Murray, HC |year=1952 |title=Microbiological oxygenation of steroids at carbon 11 |journal=J Am Chem Soc |volume=74 |issue=7 |pages=1871–2 |doi=10.1021/ja01127a531] 11α-oxygenation of Compound S produces 11α-hydrocortisone, which can be chemically oxidized tocortisone , or converted by further chemical steps to 11β-hydrocortisone (cortisol).Subsequent fermentation processes for the microbial 11β-oxygenation of steroids in a single step were developed that could convert Compound S directly to 11β-hydrocortisone (cortisol).
ee also
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Adrenosterone References
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