Artelinic acid

Artelinic acid

IUPAC_name = 4- [("3R,5aS,6R,8aS,9R,10S,12R,12aR")-decahydro-
3,6,9-trimethyl-3,12-epoxy-12"H"-pyrano [4,3-j] -1,2-
benzodioxepin-10-yl] oxy] methylbenzoic acid

width = 250px
CAS_number = 120020-26-0
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PubChem = 180423
DrugBank =
C = 23 | H = 30 | O = 7
molecular_weight = 418.48 g/mol
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Artelinic acid (or its salt, artelinate) is an experimental drug that is being investigated as a treatment for malaria. [cite journal | author=Bustos MD, Gay F, Diquet B. | year=1994 | title=In-vitro tests on Philippine isolates of "Plasmodium falciparum" against four standard antimalarials and four qinghaosu derivatives. | journal=Bull World Health Org | volume=72 | pages=729–35 ] It is a semi-synthetic derivative of the natural compound artemisinin. Artelinic acid has a lower rate of neurotoxicity than the related artemisin derivatives arteether and artemether, [cite journal | author=Genovese RF, Newman DB, Brewer TG | year=2000 | title=Behavioural and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate, in rats. | journal=Pharmacol Biochem Behav | volume=67 | pages=37–44 | doi=10.1016/S0091-3057(00)00309-9 ] but is three times more toxic than artesunate. [cite journal | author=Li Q, Xie LH, Johnson TO, "et al." | title=Toxicity exaluation of artesunate and artelinate in "Plasmodium berghei"-infected and uninfected rats | journal=Trans R Soc Trop Med Hyg Z | year=2007 | volume=101 | issue=2 | pages=104–12 | doi=10.1016/j.trstmh.2006.04.010 ] At present, artelinic acid seems unlikely to enter routine clinical use, because it offers no clear benefits over the artemesinins already available (artesunate and artemether). Artelinic acid has not yet been evaluated for use in humans.


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  • Artemisinin — Systematic (IUPAC) name (3R,5aS,6R,8aS,9R,12S,12aR) octahydro 3,6,9 trimethyl 3,12 epoxy 12H pyrano[4,3 j] 1,2 benzodioxepin 10(3H) one …   Wikipedia

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