- Allantoin
Chembox new
ImageFile = Allantoin_chemical_structure.png
ImageSize = 150px
IUPACName = (2,5-Dioxo-4-imidazolidinyl) urea
OtherNames = • Alcloxa
• Aldioxa
• Udder cream
• Ureidohydantoin
•Glyoxyldiureide
•Hemocane
• 5-Ureidohydantoin
• Vitamin U (formerly) [cite book |title=Staying Healthy With Nutrition: The Complete Guide to Diet and Nutritional Medicine |last=Haas |first=Elson M. |year=1992 |publisher=Celestial Arts |isbn=0890874816 ]
Section1 = Chembox Identifiers
CASNo = 97-59-6
PubChem =
SMILES = O=C1C(NC(=O)N1)NC(=O)N
Section2 = Chembox Properties
C=4|H=6|N=4|O=3
Appearance =
Density =
MeltingPtC = 239
BoilingPt =
Solubility = 0.5% at 25 °C
Section3 = Chembox Hazards
ExternalMSDS = [http://www.sciencelab.com/xMSDS-Allantoin-9922829 Allantoin MSDS (PDF)]
MainHazards =
FlashPt =
Autoignition =Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide. It is a
diureide ofglyoxylic acid . Named after theallantois , anamniote embryonic excretory organ in which it concentrates during development in mostmammal s except humans and higher apes, it is a product of oxidation ofuric acid bypurine catabolism . After birth, it is the predominant means by whichnitrogenous waste is excreted in theurine of these animals. [cite journal |title= The absorption and excretion of allantoin in mammals| author= Young E. G., Wentworth H. P., Hawkins W. W. | journal= J. Pharmacol. Experi. Therapeutics | volume= 81 | pages= 1–9| year= 1944 | url=http://jpet.aspetjournals.org/cgi/reprint/81/1/1 ] In humans and higher apes, the metabolic pathway for conversion ofuric acid to allantoin is not present, so the former is excreted. Recombinantrasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further (intoammonia ) before excretion. [cite journal |last=Fujiwara |first=S |coauthors=Noguchi T |year=1995 |month=November |title=Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals |journal=The Biochemical Journal |volume=312 |issue=Pt 1 |pages=315–8 |accessdate= 2007-12-21 |pmid=7492331 ] Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.Applications
Allantoin is present in botanical
extract s of thecomfrey plant anduric acid from cows, most mammals. Chemically synthesized bulk allantoin is natural-identical, safe, non-toxic, compatible with cosmetic raw materials, and meets CTFA and JSCI requirements. [Akema (an allantoin manufacturer) [http://www.akema.it/allantoin.htm] ] Over 10,000patents reference allantoin. [Patent Lens search [http://www.patentlens.com/patentlens/structured.cgi?q=allantoin+#list] ] Manufacturers cite several beneficial effects for allantoin as an active ingredient in over-the-counter cosmetics:a moisturizing andkeratolytic effect, increasing the water content of theextracellular matrix and enhancing thedesquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promotion of cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents. [www.in-cosmetics.com trade exhibition [www.in-cosmetics.com/ExhibitorLibrary/58/ALLANTOIN_CTFA.pdf] ] It is frequently present intoothpaste ,mouthwash , and otheroral hygiene products, inshampoo s,lipstick s, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products. Allantoin has not been proven scientifically to reduce the appearance of aging. [cite journal |last=Thornfeldt |first=C |year=2005 |month=July |title=Cosmeceuticals containing herbs: fact, fiction, and future |journal=Dermatologic Surgery |volume=31 |issue=7 Pt 2 |pages=873–80 |pmid=16029681 |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=16029681 |accessdate= 2007-12-21 ]See also
*
Imidazolidinyl urea anddiazolidinyl urea ,antimicrobial condensation products of allantoin withformaldehyde References
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