Cgk733

CGK733 is a synthetic substance whose molecular structure is shown in the diagram,cite web|url=http://pubs.acs.org/cen/news/84/i25/8425notw4.html|work=Chemical & Engineering News|title=Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells|year=2006|author=Sarah Everts|accessdate=2007-03-09] however the entire work behind the discovery of this compound was called into question and then found to be falsified. cite web|url=http://sciencenow.sciencemag.org/cgi/content/full/2008/305/1|work=Science|title=South Korean Researcher Suspended Over Charges of Scientific Misconduct|year=2008|author=Dennis Normile and Jennifer Couzin|accessdate=2008-03-17] cite web|url=http://pubs.acs.org/isubscribe/journals/cen/86/i12/html/8612notw3.html|work=Chemical & Engineering News|title=Data Duping|year=2008|author=Kenneth J. Moore|accessdate=2008-04-01]

It is a complex thiourea derivative which has remarkable properties in reversing cell senescence (aging).Experiments have shown that it can extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells. Current research is investigating its potential uses in wound healing, antiaging cosmetics and tissue engineering.

Tae Kook Kimcite web|url=http://bio.kaist.ac.kr/%7echemgen/professor_construction.htm|work=Molecular Genomics & Medicinal Systems Biology|title=Professor Tae Kook Kim|accessdate=2007-03-09] and several associates at the Korea Advanced Institute of Science & Technology discovered its properties as a result of screening twenty thousand synthetic molecules for their effects on aging cells.

It is an inhibitor of ATM/ATR kinases, which are involved in DNA damage repair.

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