Anti-idiotypic

Anti-idiotypic

Anti-idiotypic vaccines comprise antibodies that have three-dimensional immunogenic regions, designated idiotopes, that consist of protein sequences that bind to cell receptors. Idiotopes are aggregated into idiotypes specific of their target antigen.

Production and use

In one example of producing an anti-idiotypic vaccine, antibodies that bind tumor-associated antigens (TAA) are isolated and injected into mice. To the murine immune system, the TAA antibodies are antigens and cause an immunogenic reaction producing murine antibodies that can bind to the "TAA idiotype" and is said to be "anti-idiotypic". The resulting murine antibodies are harvested and used to vaccinate other mice. The resulting antibodies in the second set of mice have a three-dimensional binding site that mimics the structure, "i. e.", idiotopes, of the original TAA, i.e., they present the idiotype of the TAA. These antibodies are combined with an adjuvant and given as a vaccine. The murine immune system essentially "amplifies" a small mass of TAA antibodies into a much larger mass used to vaccinate humans. Because the antibody produced using the "anti-idiotypic" process closely resembles the antigen, these antibodies can be used to induce immune responses from cellular to antibody-antigen for a given antigen, "e. g.", TAA, when administered as a vaccine to a human. They are mainly used for high risk cancer patients.

References

*"Ansel's Pharmaceutical Dosage Forms and Drug Delivery System" (Page 513) (ISBN 0-7817-4612-4)


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Look at other dictionaries:

  • anti-idiotypic — an·ti idiotypic …   English syllables

  • anti-idiotypic — adjective see anti idiotype …   New Collegiate Dictionary

  • anti-idiotypic — adjective see anti idiotype …   Useful english dictionary

  • auto–anti-idiotypic antibodies — autologous anti idiotype antibodies that suppress the immune response in many experimental situations; auto–anti idiotypic antibodies occur in certain autoimmune disorders …   Medical dictionary

  • anti-idiotype — anti idiotypic /an tee id ee euh tip ik, an tuy /, adj. /an tee id ee euh tuyp , an tuy /, n. Immunol. a molecular arrangement on an antibody that is the counterpart of that on a different antibody, thus making one an antigen to the other. * * * …   Universalium

  • anti-idiotype — noun Date: 1975 an antibody that binds to the antigen combining site of another antibody either suppressing or enhancing the immune response • anti idiotypic adjective …   New Collegiate Dictionary

  • anti-id — /an tee id , an tuy /, n. Immunol. Informal. an anti idiotypic antibody. [by shortening] * * * …   Universalium

  • anti-id — /an tee id , an tuy /, n. Immunol. Informal. an anti idiotypic antibody. [by shortening] …   Useful english dictionary

  • anti-idiotype — an·ti id·io·type (an″te idґe o tīp) an antibody directed against an idiotypic determinant of another antibody. See idiotype–anti idiotype network, under network …   Medical dictionary

  • idiotype–anti-idiotype network — a regulatory mechanism mounted in response to the unique or idiotypic determinants of lymphocytes or antibodies upon antigenic stimulation. Activation of a B cell results in a clone of plasma cells producing immunoglobulin of a single idiotype,… …   Medical dictionary

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