Toxocariasis

Infobox_Disease
Name = PAGENAME


Caption = "Toxocara canis"
DiseasesDB = 29739
ICD10 = ICD10|B|83|0|b|65 (ILDS B83.01)
ICD9 = ICD9|128.0
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 2293
eMedicine_mult = eMedicine2|ped|2270 | MeshID = D014120

Toxocariasis (Toxocarosis) is a helminth infection of humans caused by the dog or cat roundworm, "Toxocara canis" or "Toxocara cati", respectively. Humans can become infected by ingestion of embryonated eggs (containing fully developed larva L3) from contaminated sources. There are two main syndromes; visceral larva migrans (VLM), which encompasses diseases associated with major organs, and ocular larva migrans (OLM), in which toxocariasis pathological effects on the host are restricted to the eye and the optic nerve.cite journal |author= Despommier D. |title=Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects |journal=Clin Microbiol Rev|volume=16 |issue=2 |pages=265–272 |year=2003 |pmid=12692098 |doi= 10.1128/CMR.16.2.265-272.2003]

Epidemiology

Toxocariasis occurs around the world. Epidemiologic surveys show a 2-5% positive rate in healthy adults from urban Western countries and 14.2-37% in rural areas.cite web | last = Huh | first = Sun | coauthors = Lee, Sooung | title = Toxocariasis | publisher = eMedicine.com | date = 2006 | url = http://www.emedicine.com/med/topic2293.htm | accessdate = 2007-03-27 ] In tropical countries, surveys show a positive rate of 63.2% in Bali, 86% in Saint Lucia, and 92.8% in Réunion. Toxocariasis is most commonly a disease of children, typically children aged 2-7 years.

Risk factors

*Exposure to contaminated soil.
*Presence of unwormed pups, unhygenic conditions.
*Geophagia (pica)- 2-10% of children aged 1-3 indulge in habitual geophagia.

Pathophysiology

Adult worms of the "Toxocara" family often live in the small intestine of dogs and cats. They range from 4-12 cm in length. Almost all puppies are infected at or soon after birth. During the summer, "Toxocara" infective eggs are shed. They survive for years in the environment, and humans typically ingest the eggs orally by eating with contaminated hands (Most commonly from handling infected feces with bare hands). Once introduced into the human intestine, the eggs develop into larvae. The larval form is less than 0.5 mm in length and 0.02 mm wide. The larvae penetrate the bowel wall and migrate through blood vessels to reach the liver, muscles, and lungs. Sometimes the parasite penetrates into the eye and brain.

Disease severity is affected by the number of eggs ingested, duration of infection, tissue location of larvae, and the immune response to the infection.

Features

* Weakness
* Pruritus (Itching)
* Rash
* Difficulty breathing
* Abdominal pain / Hepatosplenomegaly
* Hyper-eosinophilia
* Increased total serum Immunoglobulin E (IgE) level
* Elevated antibody titers to "T. canis"

Diagnosis

In suspected cases, diagnosis is confirmed by an increase in the anti-"Toxocara" excretory-secretory antigen IgE levelHistory of exposure to dogs and catsHigh Sustained eosinophilia + hyperglobulinemia + hepatomegaly
liver biopsy shows degenerated larvae at the centre of an eosinophilic granuloma

See also: List of parasites (human)

Treatment

Anthelmintic treatment, e.g. mebendazole, thiabendazole and diethylcarbamazine.
Albendazole is the more modern form of treatment.Management with anti-inflammatory steroids is also an option.

Prognosis

Toxocariasis is always a benign, asymptomatic, and self-limiting disease, although brain involvement can cause brain damage, meningitis, encephalitis, or epilepsy. Ocular involvement, also known as 'ocular larvae migrans,' may cause loss of visual acuity or unilateral blindness. Pulmonary and hepatic forms can cause protracted symptoms if the patient does not receive treatment.

Prevention

The eggs of "Toxocara" species are widespread in parks, playgrounds, yards, and in homes and apartments where the occupants have dogs or cats. Elimination of eggs from the environment is not possible; therefore, prevention depends on proper hygiene, including handwashing after contact with pets. Public policies that have attempted to eradicate "Toxocara" infection in dogs and cats have had limited success.

ee also

* List of parasites (human)

References

External links

* CDC information page on [http://www.dpd.cdc.gov/dpdx/HTML/Toxocariasis.htm toxocariasis] .
* [http://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=498 Roundworms: Cats and Kittens from The Pet Health Library]
* [http://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=476 Roundworms: Dogs and Puppies from The Pet Health Library]