SMAC (disambiguation)

SMAC may refer to:

* Sid Meier's Alpha Centauri
* Sacramento Metropolitan Arts Commission - art council in California, USA.
* Small ANSI C Interpreter
* Second mitochondria-derived activator of caspases, a component of the apoptosis pathway
* Simple media access controller, a code stack used for developing RF transceiver applications
* Securities Management and Control functionality in AMTrust.
* The Simulation Model for Automobile Collisions, a set of algorithms used in accident reconstruction to simulate car crashes.