- Tropheryma whipplei
Taxobox
color = lightgrey
name = "Tropheryma whipplei"
regnum = Bacteria
phylum =Actinobacteria
classis =Actinobacteria
subclassis =Actinobacteridae
ordo =Actinomycetales
genus =Tropheryma
species = "T. whipplei"
binomial = "Tropheryma whipplei"
binomial_authority = La Scola "et al" 2001"Tropheryma whipplei", formerly called "Tropheryma whippelii", [cite journal |author=Liang Z, La Scola B, Raoult D |title=Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei |journal=Clin. Diagn. Lab. Immunol. |volume=9 |issue=1 |pages=156–9 |year=2002 |month=January |pmid=11777846 |pmc=119894 |doi= |url=http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846] is a bacterium and the causative organism of
Whipple's disease .cite journal |author=La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D |title=Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus |journal=Int. J. Syst. Evol. Microbiol. |volume=51 |issue=Pt 4 |pages=1471–9 |year=2001 |month=July |pmid=11491348 |doi= |url=http://ijs.sgmjournals.org/cgi/pmidlookup?view=long&pmid=11491348]While "T. whipplei" is categorized with the
Gram-positive Actinobacteria , the organism is commonly found to beGram-negative or Gram-indeterminate when stained in the laboratory. Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case. [cite journal | author=Whipple GH. | title=A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues | journal=Johns Hopkins Hosp Bull | year=1907 | volume=18 | pages=382–91 ]History of the name
No name was given to the organism until
1991 when the name "Tropheryma whippelii" was proposed after sections of the bacterialgenome were sequenced. [cite journal |author=Relman D, Schmidt T, MacDermott R, Falkow S |title=Identification of the uncultured bacillus of Whipple's disease |journal=N Engl J Med |volume=327 |issue=5 |pages=293–301 |year=1992 |pmid=1377787] The name was changed to "Tropheryma whipplei" in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.Pathogenesis
:mainarticle|Whipple's disease
References
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