- Tetanolysin
Tetanolysin is a
toxin produced by "Clostridium tetani " bacteria."Clostridium tetani", the causative agent of the disease
tetanus , produces twoexotoxin s, tetanolysin andtetanospasmin . The function of tetanolysin is not known with certainty but there is data that suggests tetanolysin may contribute to thepathogenesis of tetanus.Tetanolysin belongs to a family of protein toxins known as
cytolysin s which bind tocholesterol . Cytolysins form pores in thecytoplasmic membrane that allows for the passage ofion s and other molecules into the cell. The molecular weight of Tetanolysin is approximately 55,000 daltons. [http://www.listlabs.com/Literature/199.htm]References
*Alouf, J. (1997) pp 7-10 in "Guidebook to Protein Toxins and Their Use in Cell Biology", Ed. Rappuoli, R. and Montecucco, C. (Oxford University Press).
*Ahnert-Hilger, G., Pahner, I., and Höltje, M. (1999) "Pore-forming Toxins as Cell Biological and Pharmacological Tools." In press.
*Conti, A., Brando, C., DeBell, K.E., Alava, M.A., Hoffman, T., Bonvini, E. (1993) "J. Biol. Chem." 268, 783-791.
*Raya, S.A., Trembovler, V., Shohami, E. and Lazarovici, P. (1993) "Nat. Toxins" 1, 263-70.
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