Kyotorphin

Chembox new
Name = Kyotorphin
ImageFile = Kyotorphin.png ImageName = Chemical structure of kyotorphin
IUPACName = (2"S")-2- [(2"S")-2-Amino-3-(4-hydroxyphenyl)propanoyl] amino] -5-(diaminomethylideneamino)pentanoic acid
OtherNames = Kiotorphin
L-Tyrosyl-L-Arginine
Section1 = Chembox Identifiers
PubChem = 123804
CASNo = 70904-56-2
SMILES = C1=CC(=CC=C1C [C@@H] (C(=O)N [C@@H] (CCCN=C(N)N)C(=O)O)N)O
Section2 = Chembox Properties
Formula = C₁₅H₂₃N₅O₄
MolarMass = 337.374 g/mol
Density =
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Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979. [cite journal |author=Takagi H, Shiomi H, Ueda H, Amano H |title=A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser |journal=Nature |volume=282 |issue=5737 |pages=410–2 |year=1979 |month=November |pmid=228202 |doi= |url=] Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing an Met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that it is lower in patients with persistent pain. [cite journal |author=Nishimura K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H |title= [Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain] |language=Japanese |journal=Masui |volume=40 |issue=11 |pages=1686–90 |year=1991 |month=November |pmid=1766121 |doi= |url=]

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