Manchester score

Manchester score is an indicator of prognosis in small cell lung cancer.^[1][2] It is calculated from a number of physical and biochemical markers.

A patient with small cell lung cancer scores one point for each of the following: -

• Serum lactate dehydrogenase exceeds the upper limit of the reference range.
• Serum sodium concentration less than 132 mmol/l.
• Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
• Serum bicarbonate less than 24.
• Karnofsky performance status less than 60.
• Extensive stage disease.

Prognosis

Prognosis of small cell lung cancer according to Manchester score^[3]

Manchester score	Prognostic group	Two year survival (%)
0-1	Good	16.2
2-3	Medium	2.5
4 or more	Poor	0

References

1. ^ Cerny, T; Blair V, Anderson H et al. (1987). "Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients". International Journal of Cancer 39 (2): 146–149. doi:10.1002/ijc.2910390204. PMID 3026969. 
2. ^ Kawahara, Masaaki; Masahiro Fukuoka, Nagahiro Saijo et al. (1996). "Prognostic factors and prognostic staging system for small cell lung cancer". Japanese Journal of Clinical Oncology (Oxford University Press) 27 (3): 158–165. doi:10.1093/jjco/27.3.158. PMID 9255270. ISSN: 0368-2811. http://jjco.oxfordjournals.org/cgi/content/full/27/3/158. 
3. ^ Maestu, I; Pastor M, Gómez-Codina J et al. (Jun 1997). "Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients". Annals of Oncology 8 (6): 547–553. doi:10.1023/A:1008212826956. PMID 9261523. http://annonc.oxfordjournals.org/cgi/reprint/8/6/547.