Grimm's hydride displacement law

Grimm's Hydride Displacement Law is an early hypothesis to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.Ref|Grimm1925Ref|Grimm1929

:“Atoms anywhere up to four places in the periodic system before an inert gas change their properties by uniting with one to four hydrogen atoms, in such a manner that the resulting combinations behave like pseudoatoms, which are similar to elements in the groups one to four places respectively, to their right.”Ref|Patani1996

According to Grimm, each vertical column (of Table 1) would represent a group of isosteres.

References

# Grimm, H. G. "Structure and Size of the Non-metallic Hydrides" "Z. Electrochem." 1925, "31", 474-480.
# Grimm, H. G. "On the Systematic Arrangement of Chemical Compounds from the Perspective of Research on Atomic Composition; and on Some Challenges in Experimental Chemistry." "Naturwissenschaften" 1929, "17", 557-564.
# Patani, G. A.; LaVoie, E. J. "Bioisosterism: A Rational Approach in Drug Design." "Chem. Rev." 1996, "96", 3147-3176. (DOI|10.1021/cr950066q)