Grimm's hydride displacement law

Grimm's hydride displacement law

Grimm's Hydride Displacement Law is an early hypothesis to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.Ref|Grimm1925Ref|Grimm1929

:“Atoms anywhere up to four places in the periodic system before an inert gas change their properties by uniting with one to four hydrogen atoms, in such a manner that the resulting combinations behave like pseudoatoms, which are similar to elements in the groups one to four places respectively, to their right.”Ref|Patani1996

According to Grimm, each vertical column (of Table 1) would represent a group of isosteres.

References

# Grimm, H. G. "Structure and Size of the Non-metallic Hydrides" "Z. Electrochem." 1925, "31", 474-480.
# Grimm, H. G. "On the Systematic Arrangement of Chemical Compounds from the Perspective of Research on Atomic Composition; and on Some Challenges in Experimental Chemistry." "Naturwissenschaften" 1929, "17", 557-564.
# Patani, G. A.; LaVoie, E. J. "Bioisosterism: A Rational Approach in Drug Design." "Chem. Rev." 1996, "96", 3147-3176. (DOI|10.1021/cr950066q)


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Bioisostere — In medicinal chemistry, bioisosteres are substituents or groups with similar physical or chemical properties that impart similar biological properties to a chemical compound. In drug design, the purpose of exchanging one bioisostere for another… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”