Locus control region

Locus control region

Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations.

The LCR was identified over 20 years ago. In transgenic mouse studies it was determined that the LCR was required for normal regulation of beta-globin gene expression.Mark B. Gerstein "et al.", "What is a gene, post-ENCODE? History and updated definition," "Genome Research" 17(6) (2007): 669-681] Several models exist for how the LCR exerts its effects on transcription from a distance.

1. Looping model: LCR section of the DNA loops around to different extent over the desired gene of expression, so that the binding site of the transcriptional machinery (proteins) is in physical close proximity to bridge and affect the transcription of that specific gene.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Locus control region — La Locus control region est une séquence d ADN qui va stimuler la transcription d ADN en fonction du contexte moléculaire de la cellule (lié au nombre de copies d ARNm de ce gène déjà transcrite, permet le maintien d un nombre suffisant de copies …   Wikipédia en Français

  • locus control region — (= control region; LCR) Region of DNA which contains the promoters and enhancers that regulate the expression of a particular gene. Often taken to be a single region 0 2kb upstream of the transcriptional start site, although there are probably… …   Dictionary of molecular biology

  • locus control region — (LCR) a segment of DNA situated apart from a structural gene or cluster of genes but acting in cis to increase the transcriptional activity of the gene or cluster, probably by opening and remodeling chromatin structure …   Medical dictionary

  • Human β-globin locus — The human β globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin. This locus contains not only the beta globin… …   Wikipedia

  • Locus — The place, in Latin.. In genetics, a locus is the place a gene occupies on a chromosome. One locus, two loci. * * * 1. A place; usually, a specific site. 2. The position that a gene occupies on a chromosome. 3. The position of a point, as defined …   Medical dictionary

  • Locus ceruleus — Infobox Brain Name = Locus ceruleus Latin = locus caeruleus GraySubject = 187 GrayPage = 778 Caption = Rhomboid fossa. (Locus ceruleus not labeled, but region is very near colliculus facialis, which is labeled at center left.) Caption2 = IsPartOf …   Wikipedia

  • Nonlinear control — is the area of control engineering specifically involved with systems that are nonlinear, time variant, or both. Many well established analysis and design techniques exist for LTI systems (e.g., root locus, Bode plot, Nyquist criterion, state… …   Wikipedia

  • Quantitative Trait Locus — Darstellung eines QTL für Osteoporose auf dem menschlichen Chromosom 20 (Quelle: PLoS Biology, 2003) Als Quantitative Trait Locus (abgekürzt QTL, Mehrzahl Quantitative Trait Loci, deutsch: Region eines quantitativen Merkmals) wird in der Genetik… …   Deutsch Wikipedia

  • LCRB — locus control region beta …   Medical dictionary

  • LCRB — • locus control region beta …   Dictionary of medical acronyms & abbreviations

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”