Atripla

Drugbox
type = combo
component1 = Tenofovir
class1 = Nucleotide analogue reverse transcriptase inhibitor
component2 = Emtricitabine
class2 = Nucleoside reverse transcriptase inhibitor
component3 = Efavirenz
class3 = Non-nucleoside reverse transcriptase inhibitor
CAS_number =
ATC_prefix = J05
ATC_suffix = AR06
PubChem =
DrugBank =
pregnancy_AU =
pregnancy_US = D
pregnancy_category=
legal_AU =
legal_CA =
legal_UK = POM
legal_US = Rx-only
legal_status =
routes_of_administration = Oral

Atripla is a fixed dose combination drug for the treatment of HIV infection. It combines Gilead Sciences's tenofovir and emtricitabine (already available in the anti-HIV combination Truvada) with Bristol-Myers Squibb's efavirenz into a fixed-dose pill. Combining the three drugs into a single, once-daily pill reduces pill burden and simplifies dosing schedules, and therefore has the potential to increase adherence to antiretroviral therapy.

Atripla is the first multi-class antiretroviral drug available in the United States and represents the first collaboration between two U.S. pharmaceutical companies to combine their patented anti-HIV drugs into one product. The drug costs approximately $1,150 USD for a one-month supply. As of 2007, in India it costs $1,344 USD per year and in Africa $528 USD. It was approved by the U.S. FDA on July 12 2006.

Atripla is a fixed dose combination of 600 mg Efavirenz, 300 mg Tenofovir, and 200 mg Emtricitabine. In adults, it is taken once daily on an empty stomach. Dosing at bedtime is recommended to improve tolerability of nervous system symptoms. Atripla is not recommended for patients under 18 years of age.

Atripla is a pink, capsule-shaped tablet with "123" impressed on one side.

In North America and Europe, Atripla is marketed jointly by Gilead Sciences and Bristol-Myers Squibb, but in much of the developing world, marketing and distribution is handled by Merck & Co. [ [http://www.medicalnewstoday.com/articles/63612.php Merck to Register Lower Cost of Antiretroviral Atripla in Developing Countries] ] In India, Cipla has released its own copy of Atripla, called Viraday.

Side Effects and Medical Interactions

Common side effects of Atripla are tiredness, dizziness, stomach and intestinal upset, and skin discoloration. More severe side effects are hallucinations and sleeplessness. [ [https://www.atripla.com/ Atripla official website.] ]

According to the official Atripla website, medications that should not be taken with Atripla are "Hismanal (astemizole), Vascor (bepridil), Propulsid (cisapride), Versed (midazolam), Orap (pimozide), Halcion (triazolam), or ergot derivatives (for example, Wigraine and Cafergot)." Discuss any other HIV or hepatitis medications you are taking with your doctor to avoid complications. Additionally, St. John’s wort is known to reduce the effectiveness of Atripla, resulting in increased viral load and possible resistance to Atripla. [ [https://www.atripla.com/ Atripla official website.] ]

References

External links

* [http://atripla.com Atripla.com] managed by Gilead Sciences and Bristol-Myers Squibb
* [http://thebody.com/fda/atripla.html Atripla] article on The Body, an HIV reference site