Santa Maria del Molise

Infobox CityIT
img_coa = SantaMariadelMolise-Stemma.gif
img_coa_small = yes
official_name = Comune di Santa Maria del Molise
region = Molise
province = Isernia (IS)
elevation_m =
area_total_km2 = 17
population_as_of = 2001
population_total = 653
population_density_km2 =38
timezone = CET, UTC+1
coordinates = coord|41|33|N|14|22|E|display=inline,title
frazioni = Sant'Angelo in Grotte, Cagnacci, Pagliarelle, Pizzillitti
telephone = 0865
postalcode = 86090
gentilic =
saint =
day =
mayor =
website =

Santa Maria del Molise is a town and commune in the Province of Isernia, in the Molise region (southern Italy).