Kininogen

Kininogen

Kininogens are proteins that are defined by their role as precursors for kinin, but that also can have additional roles.

The two main types are:
* High-molecular-weight kininogen, which is produced by the liver together with prekallikrein. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity.
* Low-molecular-weight kininogen, which is produced locally by numerous tissues, and secreted together with tissue kallikrein.

External links

*
* [http://nic.sav.sk/logos/books/scientific/node31.html The kinin-forming system at sav.sk]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Kininogen — Kinine sind zu den Gewebshormonen zählende biologisch aktive Oligopeptide, sie werden von Kallikrein aus Kininogenen (inaktive Vorstufe von Kininen) freigesetzt. Das Kinin Kallikrein System oder einfach Kininsystem ist ein schlecht abgrenzbares… …   Deutsch Wikipedia

  • kininogen — Inactive precursor in plasma from which kinin is produced by proteolytic cleavage …   Dictionary of molecular biology

  • kininogen — noun Any of a set of proteins defined by their primary role as precursors for kinin …   Wiktionary

  • kininogen — The globulin precursor of a (plasma) kinin. high molecular weight k. a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with …   Medical dictionary

  • kininogen — ki|ni|no|gen [↑ gen] ↑ Kinin …   Universal-Lexikon

  • kininogen — ki·nin·o·gen …   English syllables

  • kininogen — …   Useful english dictionary

  • High-molecular-weight kininogen — (HMWK), also known as the Williams Fitzgerald Flaujeac factor or the Fitzgerald factor or the HMWK kallikrein factor, is a protein from the blood coagulation system as well as the kinin kallikrein system. It is a protein that adsorbs to the… …   Wikipedia

  • Low-molecular-weight kininogen — is a form of kininogen, which has been identified in mice, [cite journal |author=Shesely E, Hu C, Alhenc Gelas F, Meneton P, Carretero O |title=A second expressed kininogen gene in mice |journal=Physiol Genomics |volume=26 |issue=2 |pages=152–7… …   Wikipedia

  • high-molecular-weight kininogen — (HMWK) a kininogen of molecular weight 100,000–250,000 that is split by plasma kallikrein to produce bradykinin. Called also Fitzgerald factor …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”