ZFYV9E (protein)

Protbox
Name=Zinc finger FYVE domain-containing protein 9 (SARA)
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HGNCid = 6775
Symbol = ZFYVE9
AltSymbols =MADHIP
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EntrezGene = 9372
OMIM = 603755
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UniProt = O95405
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Type= Anchoring protein
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Domains= 2 FYVE domains
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Taxa= "Homo sapiens"; homologs: many metazoan phyla
Cells= ubiquitous
Location= Cytoplasm
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Names=Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Smad anchor for receptor activation, Receptor activation anchor, hSARA, Novel serine protease, NSP
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Zinc finger FYVE domain-containing protein 9 or SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.