Phosphoglucomutase

Phosphoglucomutase

Phosphoglucomutase (EC number|5.4.2.2) is an enzyme that transfers a phosphoryl group on a glucose monomer from the 1' to the 6' position in the forward direction or the 6' to the 1' position in the reverse.

More specifically, it facilitates the interconversion of glucose 1-phosphate and glucose 6-phosphate.

Function in glycogenolysis

After glycogen phosphorylase has broken off a single glucose molecule from the greater glycogen structure, the free glucose has a phosphate group on its 1-carbon. This glucose-1-phosphate isomer cannot be metabolized easily. The enzyme phosphoglucomutase phosphorylates the 6-carbon, while subsequently dephosphorylating the 1-carbon. The result is glucose-6-phosphate, which can now theoretically travel down the glycolysis or pentose phosphate pathway.

Function in glycogenesis

Phosphoglucomutase also acts in the opposite fashion when a large concentration of glucose-6-phosphate is present. In this case, it is the 1-carbon that is phosphorylated and the 6-carbon that is dephosphorylated. The resulting glucose-1-phosphate is then changed into UDP-glucose in a number of intermediate steps. If activated by insulin, glycogen synthase will proceed to clip the glucose from the UDP-glucose complex and on to the glycogen molecule.

Genes

* PGM1, PGM2, PGM3, PGM5

ee also

* mutase
* Beta-phosphoglucomutase

External links

*


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Look at other dictionaries:

  • Phosphoglucomutase — Masse/Länge Primärstruktur 561 Aminosäuren …   Deutsch Wikipedia

  • Phosphoglucomutase 3 — Phosphoglucomutase 3, also known as PGM3, is a human gene.cite web | title = Entrez Gene: PGM3 phosphoglucomutase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5238| accessdate = ] PBB Summary section… …   Wikipedia

  • Phosphoglucomutase — La phosphoglucomutase est une enzyme de la glycogénogenèse qui catalyse la réaction : glucose 6 phosphate → glucose 1 phosphate Comme toutes les mutases, son action ne consiste qu à déplacer un groupement phosphate entre deux carbones d une… …   Wikipédia en Français

  • phosphoglucomutase — phosphoglucomutase. См. глюкозофосфомутаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • phosphoglucomutase — noun Date: 1938 an enzyme found in all plant and animal cells that catalyzes the reversible isomerization of glucose 1 phosphate to glucose 6 phosphate …   New Collegiate Dictionary

  • phosphoglucomutase — noun Any enzyme that catalyzes the interconversion of isomers of glucose phosphates …   Wiktionary

  • phosphoglucomutase — An enzyme that catalyzes the reversible reaction, α d glucose 1 phosphate ⇋ α d glucose 6 phosphate, with glucose 1,6 bisphosphate a necessary cofactor; one of the steps in glycogenolysis. SYN: glucose phosphomutase. * * * phos·pho·glu·co·mu·tase …   Medical dictionary

  • phosphoglucomutase — (PGM)    Among the first genetically polymorphic enzymes to be studied by electrophoresis …   Forensic science glossary

  • phosphoglucomutase — phos·pho·glu·co·mutase …   English syllables

  • phosphoglucomutase — ˌfäsfōˌglükō+ noun Etymology: phosph + gluc + mutase : an enzyme found in all plant and animal cells and obtained crystalline from rabbit muscle extracts that catalyzes especially the acylal ester interconversion of glucose phosphates …   Useful english dictionary

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