Oncofetal antigen

Oncofetal antigen

Oncofetal antigens are proteins which are typically present only during fetal development but are found in adults with certain kinds of cancer. These proteins are often measurable in the blood of individuals with cancer and may be used to both diagnose and follow treatment of the tumors. One example of an oncofetal antigen is alpha-fetoprotein, which is produced by hepatocellular carcinoma and some germ cell tumors. Another example is carcinoembryonic antigen, which is elevated in people with colon cancer and other tumors. Other oncofetal antigens are trophoblast glycoprotein precursor[1] and immature laminin receptor protein (also known as oncofetal antigen protein). Oncofetal antigens are promising targets for vaccination against several types of cancers.

External links

www,quantumimmunologics.com

References

  1. ^ 37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are identical, universal T-cell inducing immunogens on primary rodent and human cancers. Anticancer Res. 1999 Nov-Dec;19(6C):5535-42. PMID: 10697612

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  • oncofetal antigen — a protein normally produced only by fetal tissue but often produced by certain tumours. An example is carcino embryonic antigen (CEA), which has been used as a tumour marker, especially in colorectal carcinomas. * * * an antigenic gene product… …   Medical dictionary

  • oncofetal antigen — a protein normally produced only by fetal tissue but often produced by certain tumours. An example is carcino embryonic antigen (CEA), which has been used as a tumour marker, especially in colorectal carcinomas …   The new mediacal dictionary

  • Антиген Онкофетальный (Oncofetal Antigen) — белок, в норме вырабатываемый только тканями плода; иногда его присутствие в организме человека можно обнаружить в случае развития у него некоторых опухолей. Примером такого антигена является карциноэмбриональный антиген, который служит в… …   Медицинские термины

  • pancreatic oncofetal antigen — (POA) a glycoprotein, mol. wt. 800,000, found in fetal and neoplastic pancreatic tissue but not in that of normal adults; it also occurs at lower levels in the serum of patients with cancer at other sites and some normal adults …   Medical dictionary

  • antigen — Any substance that, as a result of coming in contact with appropriate cells, induces a state of sensitivity and/or immune responsiveness after a latent period (days to weeks) and that reacts in a demonstrable way with antibodies and/or immune… …   Medical dictionary

  • oncofetal — Relating to tumor associated substances present in fetal tissue, as o. antigens. * * * on·co·fe·tal or Brit on·co·foe·tal fēt əl adj of, relating to, or occurring in both tumorous and fetal tissues * * * on·co·fe·tal (ong″ko feґtəl)… …   Medical dictionary

  • Tumor antigen — is a substance produced in tumor cells that triggers an immune response in the host. Tumor antigens are useful in identifying tumor cells and are potential candidates for use in cancer therapy. Mechanism of tumor antigenesisNormal proteins in the …   Wikipedia

  • tumor-associated antigen — (TAA) an antigen that is associated with tumor cells; it may also be found under other conditions, as on normal cells during fetal life (oncofetal antigen) or on normal adult cells specific to certain organs (organ specific antigen), or may occur …   Medical dictionary

  • carcino-embryonic antigen — (CEA) a protein produced in the fetus but not in normal adult life. It may be produced by carcinomas, particularly of the colon, and is a rather insensitive marker of malignancy. It is an example of an oncofetal antigen that is used as a tumour… …   Medical dictionary

  • carcino-embryonic antigen — CEA a protein produced in the fetus but not in normal adult life. It may be produced by carcinomas, particularly of the colon, and is a rather insensitive marker of malignancy. It is an example of an oncofetal antigen that is used as a tumour… …   The new mediacal dictionary

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