Genipin

Genipin

Chembox new
ImageFile = genipin.png ImageSize = 180px
IUPACName = Methyl ("1R,2R,6S")-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo [4.3.0] nona-4,8-diene-5-carboxylate
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Section1 = Chembox Identifiers
CASNo = 6902-77-8
PubChem = 442424
SMILES = COC(=O)C1=CO [C@H] ( [C@H] 2 [C@@H] 1CC=C2CO)O

Section2 = Chembox Properties
Formula = C11H14O5
MolarMass = 226.226 g/mol
Appearance =
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Section3 = Chembox Hazards
MainHazards =
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Genipin is the active compound found in the gardenia fruit extract, which is used in traditional Chinese medicine to relieve the symptoms of type 2 diabetes. Research conducted at the Beth Israel Deaconess Medical Center and Harvard Medical School indicated that the chemical is indeed effective.

Genipin is an aglycone derived from an iridoid glycoside called geniposide present in fruit of "Gardenia jasminoides". Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. It has a low acute toxicity, with LD50 i.v. 382 mg/kg in mice, therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking regents. It is also used for pharmaceutical purposes, such as choleretic action for liver diseases control.

External links

* [http://news.bbc.co.uk/1/hi/health/5052212.stm Chinese remedy 'treats diabetes'] (BBC News)
* [http://www.genipin.org/ CBC Genipin]
* [http://www.wou.edu/las/physci/ch350/Projects_2006/Vaandering/Genipin.htm Introduction of genipin]


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  • Gardenia — For other uses, see Gardenia (disambiguation). Gardenia Gardenia jasminoides Scientific classification Kingdom …   Wikipedia

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