- RANK
RANK (Receptor Activator of Nuclear Factor κ B), also known as TRANCE Receptor, is a type I membrane protein which is expressed on the surface of
osteoclasts and is involved in the activation of osteoclasts upon ligand binding. It is also expressed ondendritic cell s and facilitates immune signaling. RANK ligand is found on the surface ofstromal cell s,osteoblast s, andT cell s.cite journal | author = Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ | title = Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families | journal = Endocr. Rev. | volume = 20 | issue = 3 | pages = 345–57 | year = 1999 | pmid = 10368775 | doi = 10.1210/er.20.3.345 | issn = ] cite journal | author = Wong BR, Josien R, Choi Y | title = TRANCE is a TNF family member that regulates dendritic cell and osteoclast function | journal = J. Leukoc. Biol. | volume = 65 | issue = 6 | pages = 715–24 | year = 1999 | pmid = 10380891 | doi = | issn = | url = http://www.jleukbio.org/cgi/content/abstract/65/6/715 ] cite journal | author = Theill LE, Boyle WJ, Penninger JM | title = RANK-L and RANK: T cells, bone loss, and mammalian evolution | journal = Annu. Rev. Immunol. | volume = 20 | issue = | pages = 795–823 | year = 2002 | pmid = 11861618 | doi = 10.1146/annurev.immunol.20.100301.064753 | issn = ]ee also
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RANKL
*Osteoimmunology References
External links
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Further reading
PBB_Further_reading
citations =
*cite journal | author=Romas E, Gillespie MT, Martin TJ |title=Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. |journal=Bone |volume=30 |issue= 2 |pages= 340–6 |year= 2002 |pmid= 11856640 |doi=
*cite journal | author=Collin-Osdoby P |title=Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. |journal=Circ. Res. |volume=95 |issue= 11 |pages= 1046–57 |year= 2005 |pmid= 15564564 |doi= 10.1161/01.RES.0000149165.99974.12
*cite journal | author=Clohisy DR, Mantyh PW |title=Bone cancer pain and the role of RANKL/OPG. |journal=Journal of musculoskeletal & neuronal interactions |volume=4 |issue= 3 |pages= 293–300 |year= 2005 |pmid= 15615497 |doi=
*cite journal | author=Anandarajah AP, Schwarz EM |title=Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications. |journal=J. Cell. Biochem. |volume=97 |issue= 2 |pages= 226–32 |year= 2006 |pmid= 16240334 |doi= 10.1002/jcb.20674
*cite journal | author=Baud'huin M, Duplomb L, Ruiz Velasco C, "et al." |title=Key roles of the OPG-RANK-RANKL system in bone oncology. |journal=Expert Rev Anticancer Ther |volume=7 |issue= 2 |pages= 221–32 |year= 2007 |pmid= 17288531 |doi= 10.1586/14737140.7.2.221
*cite journal | author=Boyce BF, Xing L |title=Biology of RANK, RANKL, and osteoprotegerin. |journal=Arthritis Res. Ther. |volume=9 Suppl 1 |issue= |pages= S1 |year= 2007 |pmid= 17634140 |doi= 10.1186/ar2165
*cite journal | author=Hughes AE, Shearman AM, Weber JL, "et al." |title=Genetic linkage of familial expansile osteolysis to chromosome 18q. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 359–61 |year= 1994 |pmid= 7911698 |doi=
*cite journal | author=Cody JD, Singer FR, Roodman GD, "et al." |title=Genetic linkage of Paget disease of the bone to chromosome 18q. |journal=Am. J. Hum. Genet. |volume=61 |issue= 5 |pages= 1117–22 |year= 1997 |pmid= 9345096 |doi=
*cite journal | author=Anderson DM, Maraskovsky E, Billingsley WL, "et al." |title=A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. |journal=Nature |volume=390 |issue= 6656 |pages= 175–9 |year= 1997 |pmid= 9367155 |doi= 10.1038/36593
*cite journal | author=Haslam SI, Van Hul W, Morales-Piga A, "et al." |title=Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity. |journal=J. Bone Miner. Res. |volume=13 |issue= 6 |pages= 911–7 |year= 1998 |pmid= 9626621 |doi=
*cite journal | author=Darnay BG, Haridas V, Ni J, "et al." |title=Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20551–5 |year= 1998 |pmid= 9685412 |doi=
*cite journal | author=Wong BR, Josien R, Lee SY, "et al." |title=The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28355–9 |year= 1998 |pmid= 9774460 |doi=
*cite journal | author=Galibert L, Tometsko ME, Anderson DM, "et al." |title=The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34120–7 |year= 1999 |pmid= 9852070 |doi=
*cite journal | author=Nakagawa N, Kinosaki M, Yamaguchi K, "et al." |title=RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 395–400 |year= 1999 |pmid= 9878548 |doi= 10.1006/bbrc.1998.9788
*cite journal | author=Kim HH, Lee DE, Shin JN, "et al." |title=Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. |journal=FEBS Lett. |volume=443 |issue= 3 |pages= 297–302 |year= 1999 |pmid= 10025951 |doi=
*cite journal | author=Darnay BG, Ni J, Moore PA, Aggarwal BB |title=Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7724–31 |year= 1999 |pmid= 10075662 |doi=
*cite journal | author=Hsu H, Lacey DL, Dunstan CR, "et al." |title=Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3540–5 |year= 1999 |pmid= 10097072 |doi=
*cite journal | author=Dougall WC, Glaccum M, Charrier K, "et al." |title=RANK is essential for osteoclast and lymph node development. |journal=Genes Dev. |volume=13 |issue= 18 |pages= 2412–24 |year= 1999 |pmid= 10500098 |doi=
*cite journal | author=Hughes AE, Ralston SH, Marken J, "et al." |title=Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. |journal=Nat. Genet. |volume=24 |issue= 1 |pages= 45–8 |year= 2000 |pmid= 10615125 |doi= 10.1038/71667
*cite journal | author=Wong BR, Besser D, Kim N, "et al." |title=TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. |journal=Mol. Cell |volume=4 |issue= 6 |pages= 1041–9 |year= 2000 |pmid= 10635328 |doi=PBB_Controls
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