Desoxycorticosterone

Desoxycorticosterone

drugbox
IUPAC_name =


CAS_number = 64-85-7
ATC_prefix = H02
ATC_suffix = AA03
PubChem = 6166
DrugBank =
C=21 | H=30 | O=4
molecular_weight = 330.461
bioavailability =
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metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
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Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid secreted from Zona reticularis and Zona fasciculata of the adrenal gland. In the cytosol of the mitochondrion, pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the endoplasmic reticulum. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively.

Desoxycorticosterone is commonly found in two forms: the acetate salt (desoxycorticosterone acetate, or DOCA) and the pivalate salt (desoxycorticosterone pivalate). Both forms are given as intramuscular injections as replacement therapy for Addison's disease. This disease is marked by insufficient adrenal function, including low mineralocorticoid levels.

Desoxycorticosterone pivalate is sold for veterinary use by Novartis under the brand name Percoten.

References

http://web.indstate.edu/thcme/mwking/steroid-hormones.html


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  • désoxycorticostérone — ● désoxycorticostérone nom féminin Hormone corticosurrénale favorisant la rétention des ions sodium et l excrétion des ions potassium. désoxycortone [dezɔksikɔʀtɔn] ou désoxycorticostérone [dezɔksikɔʀtikosteʀɔn] n. f. ÉTYM. Mil. XXe; de dés (→ 1 …   Encyclopédie Universelle

  • desoxycorticosterone — noun A mineralocorticoid hormone secreted by the adrenal gland. Syn: 11 deoxycorticosterone …   Wiktionary

  • desoxycorticosterone — A steroid derived from the adrenal cortex with strong mineralocorticoid activity. * * * des·oxy·cor·ti·co·ste·rone (.)dez .äk si .kȯrt i käs tə .rōn, i .kō stə rōn or de·oxy·cor·ti·co·ste·rone (.)dē n a steroid hormone C21H30O3 of the adrenal… …   Medical dictionary

  • desoxycorticosterone acetate — [USP] the acetate salt of 11 deoxycorticosterone; used as replacement therapy to treat adrenocortical insufficiency; administered by intramuscular injection …   Medical dictionary

  • desoxycorticosterone pivalate — [USP] the pivalate salt of 11 deoxycorticosterone, used as replacement therapy to treat adrenocortical insufficiency; administered by intramuscular injection …   Medical dictionary

  • DCTMA — desoxycorticosterone trimethyl acetate …   Medical dictionary

  • DCTPA — desoxycorticosterone triphenyl acetate …   Medical dictionary

  • DOC — Désoxycorticostérone. Substance favorisant, dans l organisme, la fixation du sodium et de l eau et l élimination du potassium. Contribue à l entretien de l activité musculaire …   Sigles et Acronymes francais

  • DCTMA — • desoxycorticosterone trimethyl acetate …   Dictionary of medical acronyms & abbreviations

  • DCTPA — • desoxycorticosterone triphenyl acetate …   Dictionary of medical acronyms & abbreviations

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