Urocortin

Urocortin, also known as UCN, is a human gene.cite web | title = Entrez Gene: UCN urocortin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7349| accessdate = ] PBB_Summary
section_title =
summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.cite web | title = Entrez Gene: UCN urocortin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7349| accessdate = ] Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.

References

Further reading

*Inui, Bowers, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004 Mar;18(3):439-56. [http://www.fasebj.org/cgi/content/full/18/3/439 PMID: 15003990]
*Huang Y, Yao XQ, Lau CW, Chan YC, Tsang SY, Chan FL. Urocortin and cardiovascular protection. Acta Pharmacol Sin. 2004 Mar;25(3):257-65.
*Takahashi, Kazuhiro. Translational medicine in fish-derived peptides: From fish endocrinology to human physiology and diseases. Endocrine Journal (Kyoto, Japan) (2004), 51(1), 1-17.PBB_Further_reading
citations =
*cite journal | author=Tsarev OB |title= [Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks] |journal=Biofizika |volume=22 |issue= 2 |pages= 197–200 |year= 1977 |pmid= 861256 |doi=
*cite journal | author=Donaldson CJ, Sutton SW, Perrin MH, "et al." |title=Cloning and characterization of human urocortin. |journal=Endocrinology |volume=137 |issue= 5 |pages= 2167–70 |year= 1996 |pmid= 8612563 |doi=
*cite journal | author=Adachi T, Schamel WW, Kim KM, "et al." |title=The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. |journal=EMBO J. |volume=15 |issue= 7 |pages= 1534–41 |year= 1996 |pmid= 8612576 |doi=
*cite journal | author=Iino K, Sasano H, Oki Y, "et al." |title=Urocortin expression in human pituitary gland and pituitary adenoma. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 11 |pages= 3842–50 |year= 1997 |pmid= 9360550 |doi=
*cite journal | author=Gottowik J, Goetschy V, Henriot S, "et al." |title=Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H] -urocortin. |journal=Neuropharmacology |volume=36 |issue= 10 |pages= 1439–46 |year= 1998 |pmid= 9423932 |doi=
*cite journal | author=Bamberger CM, Wald M, Bamberger AM, "et al." |title=Human lymphocytes produce urocortin, but not corticotropin-releasing hormone. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 2 |pages= 708–11 |year= 1998 |pmid= 9467598 |doi=
*cite journal | author=Takahashi K, Totsune K, Sone M, "et al." |title=Regional distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain. |journal=Peptides |volume=19 |issue= 4 |pages= 643–7 |year= 1998 |pmid= 9622018 |doi=
*cite journal | author=Zhao L, Donaldson CJ, Smith GW, Vale WW |title=The structures of the mouse and human urocortin genes (Ucn and UCN). |journal=Genomics |volume=50 |issue= 1 |pages= 23–33 |year= 1999 |pmid= 9628819 |doi= 10.1006/geno.1998.5292
*cite journal | author=Iino K, Sasano H, Oki Y, "et al." |title=Urocortin expression in the human central nervous system. |journal=Clin. Endocrinol. (Oxf) |volume=50 |issue= 1 |pages= 107–14 |year= 1999 |pmid= 10341863 |doi=
*cite journal | author=Watanabe F, Oki Y, Ozawa M, "et al." |title=Urocortin in human placenta and maternal plasma. |journal=Peptides |volume=20 |issue= 2 |pages= 205–9 |year= 1999 |pmid= 10422876 |doi=
*cite journal | author=Slominski A, Roloff B, Curry J, "et al." |title=The skin produces urocortin. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 2 |pages= 815–23 |year= 2000 |pmid= 10690896 |doi=
*cite journal | author=Muramatsu Y, Fukushima K, Iino K, "et al." |title=Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa. |journal=Peptides |volume=21 |issue= 12 |pages= 1799–809 |year= 2001 |pmid= 11150640 |doi=
*cite journal | author=Muramatsu Y, Sugino N, Suzuki T, "et al." |title=Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 3 |pages= 1362–9 |year= 2001 |pmid= 11238533 |doi=
*cite journal | author=Hsu SY, Hsueh AJ |title=Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. |journal=Nat. Med. |volume=7 |issue= 5 |pages= 605–11 |year= 2001 |pmid= 11329063 |doi= 10.1038/87936
*cite journal | author=Lewis K, Li C, Perrin MH, "et al." |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570–5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198
*cite journal | author=Kimura Y, Takahashi K, Totsune K, "et al." |title=Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 1 |pages= 340–6 |year= 2002 |pmid= 11788672 |doi=
*cite journal | author=Florio P, Arcuri F, Ciarmela P, "et al." |title=Identification of urocortin mRNA and peptide in the human endometrium. |journal=J. Endocrinol. |volume=173 |issue= 2 |pages= R9–14 |year= 2002 |pmid= 12010647 |doi=
*cite journal | author=Arcuri F, Cintorino M, Florio P, "et al." |title=Expression of urocortin mRNA and peptide in the human prostate and in prostatic adenocarcinoma. |journal=Prostate |volume=52 |issue= 3 |pages= 167–72 |year= 2002 |pmid= 12111693 |doi= 10.1002/pros.10094
*cite journal | author=Ikeda K, Tojo K, Oki Y, Nakao K |title=Urocortin has cell-proliferative effects on cardiac non-myocytes. |journal=Life Sci. |volume=71 |issue= 16 |pages= 1929–38 |year= 2002 |pmid= 12175707 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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