Bromodifluoroacetyl chloride

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IUPACName = 2-bromo-2,2-difluoro-ethanoyl chloride
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CASNo = 3832-48-2
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PubChem = 520892
SMILES = C(=O)(C(F)(F)Br)Cl
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C = 2 | O = 1 | F = 2 | Br = 1 | Cl = 1
Appearance = liquid
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Bromodifluoroacetyl chloride is a chemical compound with the formula BrCF₂COCl. It has been used as a starting material for the synthesis of (biologically active) α,α-difluoro-γ-lactams [cite journal | author = Hideo Nagashima, Yoshimi Isono, and Sho-ichi Iwamatsu | title = Copper-Catalyzed Cyclization of N-Allylhalodifluoroacetamides: An Efficient Synthesis of α,α-difluoro-γ-lactams | journal = J. Org. Chem. | volume = 66 | issue = 1 | pages = 315-319 | year = 2001 | doi = 10.1021/jo001187f] and has been used in the synthesis of trifluoromethylated C-nucleosides [cite journal | author = Constantin Mamata, Martin Heina and Ralf Miethchen | title = Fluorinated acyclo-C-nucleoside analogues from glycals in two steps | journal = Carbohydr. Res. | volume = 341 | issue = 10 | pages = 1758-1763 | year = 2006 | doi = 10.1016/j.carres.2006.01.011]

References

ee also

*Acetyl chloride
*Trifluoroacetic acid