Hesperidin

Hesperidin

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Section1= Chembox Identifiers
CASNo= 520-26-3
PubChem=10621
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Section2= Chembox Properties
Formula=C28H34O15
MolarMass=610.56056
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Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to "in vitro" studies. [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16101151&query_hl=33&itool=pubmed_docsum Kinetics of radical-scavenging activity of hespere... [Anticancer Res. 2005 Sep-Oct - PubMed Result ] ] In human nutrition it contributes to the integrity of the blood vessels.

Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7495469&query_hl=21&itool=pubmed_docsum Biological effects of hesperidin, a Citrus flavono... [Farmaco. 1995 - PubMed Result ] ] and blood pressure [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14974738&query_hl=21&itool=pubmed_docsum Glucosyl hesperidin improves serum cholesterol com... [J Nutr Sci Vitaminol (Tokyo). 2003 - PubMed Result ] ] in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss. [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12771335&query_hl=16&itool=pubmed_docsum Hesperidin, a citrus flavonoid, inhibits bone loss... [J Nutr. 2003 - PubMed Result ] ] Another animal study showed protective effects against sepsis. [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15133244&query_hl=19&itool=pubmed_docsum A citrus flavonoid hesperidin suppresses infection... [Biol Pharm Bull. 2004 - PubMed Result ] ] Hesperitin has anti-inflammatory effects. [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8021799&query_hl=1&itool=pubmed_docsum Pharmacological evaluation of the anti-inflammator... [J Pharm Pharmacol. 1994 - PubMed Result ] ] [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7832973&query_hl=28&itool=pubmed_docsum Biological effects of hesperidin, a citrus flavono... [Farmaco. 1994 - PubMed Result ] ]

Some in vitro results applied only to the aglucone form. Hesperitin also showed the ability to penetrate the blood brain barrier in an in vitro model. [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12641740&query_hl=24&itool=pubmed_docsum Interaction between flavonoids and the blood-brain... [J Neurochem. 2003 - PubMed Result ] ]

References


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Look at other dictionaries:

  • Hesperidin — Hes*per i*din, n. [See {Hesperidium}.] (Chem.) A glucoside found in ripe and unripe fruit (as the orange), and extracted as a white crystalline substance. [1913 Webster] …   The Collaborative International Dictionary of English

  • Hesperidīn — Hesperidīn, von Lebreton in dem weißen, schwammigen Theil der Pomeranzen u. Citronenschalen aufgefundener Stoff; man erhält es durch Sättigung des warmen wässerigen Auszugs mit Kalkwasser, Verdampfen, Ausziehen des Rückstandes mit Alkohol,… …   Pierer's Universal-Lexikon

  • Hesperidīn — (Aurantiin) C22H26O12, Glykosid, das sich sehr verbreitet in den Früchten von Citrus Arten, auch in Bättern von Citrus Aurantium, C chinensis etc. findet, bildet mikroskopische, geruch und geschmacklose Nadeln, löst sich schwer in Wasser und… …   Meyers Großes Konversations-Lexikon

  • hesperidin — [hes per′i din] n. [< ModL hesperidium, orange (in allusion to the golden apples of HESPERIDES) + IN1] a crystalline glucoside, C28H34O15, derived from flavanone and found in the peel of many citrus fruits …   English World dictionary

  • Hesperidin — Strukturformel Allgemeines Name Hesperidin Andere Namen …   Deutsch Wikipedia

  • Hesperidin — He|spe|ri|din auch: Hes|pe|ri|din 〈n. 11; Biochem.〉 Glykosid aus den Fruchtschalen unreifer Orangen, pharmakolog. in Venen u. Grippemitteln verwendet * * * Hes|pe|ri|din [griech. Hesperídes = Töchter des Atlas (die im Westen (griech. hespérios)… …   Universal-Lexikon

  • hesperidin — heˈsperədən, |sperə|din noun ( s) Etymology: New Latin hesperidium + English in : a crystalline bioflavonoid glycoside C28H34O15 found in most citrus fruits and especially in orange peel that yields hesperitin, glucose, and rhamnose on hydrolysis …   Useful english dictionary

  • hesperidin — noun Etymology: New Latin hesperidium orange, from Latin Hesperides Date: 1838 a crystalline glycoside C28H34O15 found in most citrus fruits and especially in orange peel …   New Collegiate Dictionary

  • hesperidin — /he sper i din/, n. Biochem. a crystallizable, bioflavinoid glycoside, C28H34O15, occurring in most citrus fruits, esp. in the spongy envelope of oranges and lemons. [1830 40; < NL; see HESPERIDES, IN2] * * * …   Universalium

  • hesperidin — noun A citrus]] flavonoid]] compound, reported as the predominant flavonoid in lemons and oranges. Chemically, it is hesperetin 7 rutinoside, namely (S) 7 …   Wiktionary

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