FGF1

Fibroblast growth factor 1 (acidic), also known as FGF1, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. [cite web | title = Entrez Gene: FGF1 fibroblast growth factor 1 (acidic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2246| accessdate = ]

ee also

* Fibroblast growth factor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yu YL, Kha H, Golden JA, "et al." |title=An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. |journal=J. Exp. Med. |volume=175 |issue= 4 |pages= 1073–80 |year= 1992 |pmid= 1372643 |doi=
*cite journal | author=Chiu IM, Wang WP, Lehtoma K |title=Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. |journal=Oncogene |volume=5 |issue= 5 |pages= 755–62 |year= 1990 |pmid= 1693186 |doi=
*cite journal | author=Zhu X, Komiya H, Chirino A, "et al." |title=Three-dimensional structures of acidic and basic fibroblast growth factors. |journal=Science |volume=251 |issue= 4989 |pages= 90–3 |year= 1991 |pmid= 1702556 |doi=
*cite journal | author=Wang WP, Quick D, Balcerzak SP, "et al." |title=Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. |journal=Oncogene |volume=6 |issue= 9 |pages= 1521–9 |year= 1991 |pmid= 1717925 |doi=
*cite journal | author=Wu DQ, Kan MK, Sato GH, "et al." |title=Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. |journal=J. Biol. Chem. |volume=266 |issue= 25 |pages= 16778–85 |year= 1991 |pmid= 1885605 |doi=
*cite journal | author=Crumley G, Dionne CA, Jaye M |title=The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon. |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 1 |pages= 7–13 |year= 1990 |pmid= 2393407 |doi=
*cite journal | author=Harper JW, Strydom DJ, Lobb RR |title=Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor. |journal=Biochemistry |volume=25 |issue= 14 |pages= 4097–103 |year= 1986 |pmid= 2427112 |doi=
*cite journal | author=Winkles JA, Friesel R, Burgess WH, "et al." |title=Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 20 |pages= 7124–8 |year= 1987 |pmid= 2444975 |doi=
*cite journal | author=Wang WP, Lehtoma K, Varban ML, "et al." |title=Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues. |journal=Mol. Cell. Biol. |volume=9 |issue= 6 |pages= 2387–95 |year= 1989 |pmid= 2474753 |doi=
*cite journal | author=Mergia A, Tischer E, Graves D, "et al." |title=Structural analysis of the gene for human acidic fibroblast growth factor. |journal=Biochem. Biophys. Res. Commun. |volume=164 |issue= 3 |pages= 1121–9 |year= 1989 |pmid= 2590193 |doi=
*cite journal | author=Jaye M, Howk R, Burgess W, "et al." |title=Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. |journal=Science |volume=233 |issue= 4763 |pages= 541–5 |year= 1986 |pmid= 3523756 |doi=
*cite journal | author=Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA |title=The complete amino acid sequence of human brain-derived acidic fibroblast growth factor. |journal=Biochem. Biophys. Res. Commun. |volume=138 |issue= 2 |pages= 611–7 |year= 1986 |pmid= 3527167 |doi=
*cite journal | author=Gautschi P, Fràter-Schröder M, Böhlen P |title=Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors. |journal=FEBS Lett. |volume=204 |issue= 2 |pages= 203–7 |year= 1986 |pmid= 3732516 |doi=
*cite journal | author=Gautschi-Sova P, Müller T, Böhlen P |title=Amino acid sequence of human acidic fibroblast growth factor. |journal=Biochem. Biophys. Res. Commun. |volume=140 |issue= 3 |pages= 874–80 |year= 1986 |pmid= 3778488 |doi=
*cite journal | author=Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA |title=Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities. |journal=Biochem. Biophys. Res. Commun. |volume=135 |issue= 2 |pages= 541–8 |year= 1986 |pmid= 3964259 |doi=
*cite journal | author=Zhao XM, Yeoh TK, Hiebert M, "et al." |title=The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. |journal=Transplantation |volume=56 |issue= 5 |pages= 1177–82 |year= 1993 |pmid= 7504343 |doi=
*cite journal | author=Pineda-Lucena A, Jiménez MA, Nieto JL, "et al." |title=1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. |journal=J. Mol. Biol. |volume=242 |issue= 1 |pages= 81–98 |year= 1994 |pmid= 7521397 |doi= 10.1006/jmbi.1994.1558
*cite journal | author=Chotani MA, Payson RA, Winkles JA, Chiu IM |title=Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester. |journal=Nucleic Acids Res. |volume=23 |issue= 3 |pages= 434–41 |year= 1995 |pmid= 7533902 |doi=
*cite journal | author=Opalenik SR, Shin JT, Wehby JN, "et al." |title=The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor. |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17457–67 |year= 1995 |pmid= 7542239 |doi=
*cite journal | author=Myers RL, Payson RA, Chotani MA, "et al." |title=Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts. |journal=Oncogene |volume=8 |issue= 2 |pages= 341–9 |year= 1993 |pmid= 7678925 |doi=

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