Bafilomycin

chembox new
Reference= [ [http://www.fermentek.co.il/bafilomycin_A1.htm Bafilomycin A1 product page] from Fermentek]
Name = Bafilomycin A1
ImageFile=Bafilomycin A1.pngImageSize=250px
IUPACName= (3"Z",5"E",7"R",8"S",9"S",11"E",13"E",15"S",16"R")-16- [(1"S",2"R",3"S")-3- [(2"R",4"R",5"S",6"R")-2,4-dihydroxy-6- isopropyl-5-methyl-2-tetrahydropyranyl] -2- hydroxy-1-methylbutyl] -8-hydroxy-3,15- dimethoxy-5,7,9,11-tetramethyl-1- oxacyclohexadeca-3,5,11,13-tetraen-2-one
OtherNames=
Section1=Chembox Identifiers
CASNo=88899-55-2
PubChem=6436223
SMILES=C [C@H] 1C/C(=C/C=C/ [C@@H] ( [C@H] (OC(=O)/C(=C/C(=C/ [C@H] ( [C@H] 1O)C)/C)/OC) [C@@H] (C) [C@H] ( [C@H] (C) [C@] 2(C [C@H] ( [C@@H] ( [C@H] (O2)C(C)C)C)O)O)O)OC)/C
Section2=Chembox Properties
Formula=C₃₅H₅₈O₉
MolarMass=622.83 g/mol
Appearance=Yellow powder
Density=
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BoilingPt=
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Section3=Chembox Hazards
MainHazards=
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The bafilomycins are a family of toxic macrolide antibiotic derived from "Streptomyces griseus". These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase).

The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

Bafilomycin has antibacterial, antifungal, antineoplastic, immunosuppressive activities. It has been shown to decrease multi-drug resistance.

Bafilomycin B1 has been mentioned as a potential antiosteoporotic agent in treating bone lytic diseases.

References