Polybrene

Polybrene

Polybrene (hexadimethrine bromide) is a cationic polymer used to increase the efficiency of infection of certain cells with a retrovirus in cell culture. Polybrene acts by neutralizing the charge repulsion between the virions and cell surface. [cite journal |author=Howard E. Davis, Matthew Rosinski , Jeffrey R. Morgan and Martin L. Yarmush, "et al" |title=Charged Polymers Modulate Retrovirus Transduction via Membrane Charge Neutralization and Virus Aggregation. |journal=Biophysical Journal |volume=86 |number=2 |pages=1234–42 |year=2004 |pmid=14747357] It has other uses, including a role in protein sequencing.

The chemical name for Polybrene is 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide, hexadimethrine bromide.

References


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  • polybrene — noun A cationic polymer, hexadimethrine bromide, used to increase the efficiency of infection of certain cells with a retrovirus in cell culture …   Wiktionary

  • Protein sequencing — Proteins are found in every cell and are essential to every biological process, protein structure is very complex: determining a protein s structure involves first protein sequencing determining the amino acid sequences of its constituent… …   Wikipedia

  • PB — Symbol for barometric pressure. * * * British pharmacopeia [Pharmacopoeia Britannica]; paraffin bath; paraffin block; paucibacillary; Paul Bunnell [antibody]; periodic breathing; peripheral blood; peroneus brevis; phenobarbital; phenoxybenzamine; …   Medical dictionary

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  • PB — • British pharmacopeia [Pharmacopoeia Britannica]; • paraffin bath; • paraffin block; • paucibacillary; • Paul Bunnell [antibody]; • periodic breathing; • peripheral blood; • peroneus brevis; • phenobarbital; • phenoxybenzamine; • phonetically… …   Dictionary of medical acronyms & abbreviations

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